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PDOC00784
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1995-07-26
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* PTR2 family proton/oligopeptide symporters signatures *
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A family of eukaryotic and prokaroytic proteins that seem to be mainly
involved in the intake of small peptides with the concomitant uptake of a
proton has been recently characterized [1,2,3]. The proteins that belong to
this family are:
- Yeast peptide transporter PTR2.
- Rabbit intestine proton-dependent oligopeptide transporter PeptT1.
- Arabidopsis proton-dependent nitrate/chlorate transporter CHL1.
- Arabidopsis histidine transporter NTR1.
- Lactococcus lactis di- and tri-peptide transporter dtpT.
- Escherichia coli hypothetical protein yhiP.
These integral membrane proteins are predicted to comprise twelve
transmembrane regions. As signature patterns, we selected two of the best
conserved regions. The first pattern correspond to a region that include the
end of the second transmembrane region, a cytoplasmic loop as well as the
third transmembrane region. The second pattern corresponds to the core of the
fifth transmembrane region.
-Consensus pattern: G-[GA]-[LIVMFYW](2)-[GA]-D-x-[LIVMFYW](2)-G-x(3)-T-I-x(3)-
[GSTA]-x-[LIVM]-x(3)-G
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Consensus pattern: F-x(2)-F-[LIVMFY](2)-x-I-N-x-G-[SA]-L
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: June 1994 / First entry.
[ 1] Fei Y.-J., Kanai Y., Nussberger S., Ganapathy V., Leibach F.H.,
Romero M.F., Singh S.K., Boron W.F., Hediger M.A.
Nature 368:563-566(1994).
[ 2] Perry J.R., Basrai M.A., Steiner H.-Y., Naider F., Becker J.M.
Mol. Cell. Biol. 14:104-115(1994).
[ 3] Frommer W.B., Hummel S., Rentsch D.
FEBS Lett. 347:185-189(1994).